Sementara itu Jorge Martin berhasil mengambil alih posisi keempat setelah menyalip Takaaki Nakagami. Brad Binder dan Pol Espargaro juga mengekor di posisi keenam dan ketujuh.

Hasil FP2 MotoGP Spanyol 2022

1. Fabio Quartararo FRA Monster Yamaha (YZR-M1)

2. Enea Bastianini ITA Gresini Ducati (GP21)
3. Francesco Bagnaia ITA Ducati Lenovo (GP22)
4. Jorge Martin SPA Pramac Ducati (GP22)
5. Takaaki Nakagami JPN LCR Honda (RC213V)
6. Brad Binder RSA Red Bull KTM (RC16)
7. Pol Espargaro SPA Repsol Honda (RC213V)
8. Alex Rins SPA Suzuki Ecstar (GSX-RR)

9. Maverick Viñales SPA Aprilia Factory (RS-GP)
10. Jack Miller AUS Ducati Lenovo (GP22)
11. Johann Zarco FRA Pramac Ducati (GP22)
12. Joan Mir SPA Suzuki Ecstar (GSX-RR)
13. Aleix Espargaro SPA Aprilia Factory (RS-GP)
14. Franco Morbidelli ITA Monster Yamaha (YZR-M1)
15. Miguel Oliveira POR Red Bull KTM (RC16)
16. Alex Marquez SPA LCR Honda (RC213V)
17. Luca Marini ITA Mooney VR46 Ducati (GP22)
18. Marco Bezzecchi ITA Mooney VR46 Ducati (GP21)*

19. Marc Marquez SPA Repsol Honda (RC213V)
20. Andrea Dovizioso ITA WithU RNF Yamaha (YZR-M1)
21. Fabio Di Giannantonio ITA Gresini Ducati (GP21)*
22. Stefan Bradl GER Team HRC (RC213V)
23. Remy Gardner AUS KTM Tech3 (RC16)*
24. Darryn Binder RSA WithU RNF Yamaha (YZR-M1)*
25. Lorenzo Savadori ITA Aprilia Factory (RS-GP)